Last update Aug. 24, 2014
Inhibitor of BCR-ABL and SRC tyrosine kinase that is used for treatment of Chronic Myeloid Leukemia with positive Philadelphia chromosome.
At latest update, relevant published data on excretion into breast milk were not found.
Because of high serum protein-binding capacity, excretion into breast milk in significant amount is seemingly unlikely.
If continuation of safely breastfeeding is desired without assuming high risk for potentially severe side-effects, elimination of total burden of drug should be kept. For this to happen, it should be wait for 10 half-lives (T ½).
It means that 7 days should be waited before resuming breastfeeding.
Meanwhile, frequent pump-and-dump is recommended for maintenance of milk production.
We do not have alternatives for Nilotinib.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.
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