Last update Nov. 9, 2014

Нифлумовая Кислота

Low Risk

Possibly safe. Probably compatible. Mild risk possible. Follow up recommended. Read the Comment.

Active metabolite of Morniflumate.

At latest update, relevant information on excretion into breast milk was not found.

Due to a high serum-protein-binding capacity, excretion of Rabeprazole into breast milk in significant levels is unlikely.

Based on data offered by the manufacturer, excretion into breast milk is minimal, with a concentration in the milk which is one-hundredth less than plasma level.

Nevertheless, it would be prudent the use of anti-inflammatory drugs known to be safe while breastfeeding.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Нифлумовая Кислота is also known as Niflumic Acid. Here it is a list of alternative known names::


Group

Нифлумовая Кислота belongs to this group or family:

Tradenames

Main tradenames from several countries containing Нифлумовая Кислота in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 282 daltons
Protein Binding 90 %
VD 0.12 l/Kg
Tmax 2 hours
4 - 6 hours
M/P ratio 0.01 -

References

  1. Azzouz A, Jurado-Sánchez B, Souhail B, Ballesteros E. Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry. J Agric Food Chem. 2011 Abstract
  2. AEMPS. Ácido niflúmico. Ficha técnica 2009 Full text (in our servers)
  3. Alessandri JL, Abossolo T, Reynaud I, Montbrun A, Sommer JC, Tilmont P. [Non-steroidal anti-inflammatory agents and pregnancy. A study of renal and digestive toxicity of niflumic acid in the perinatal period]. J Gynecol Obstet Biol Reprod (Paris). 1994 Abstract
  4. Chevallier B, Baudet V, Doumaz Y, Renaud C, Costil J. [Neonatal renal insufficiency secondary to niflumic acid administration in pregnancy]. Arch Fr Pediatr. 1992 Abstract
  5. Houin G, Tremblay D, Bree F, Dufour A, Ledudal P, Tillement JP. The pharmacokinetics and availability of niflumic acid in humans. Int J Clin Pharmacol Ther Toxicol. 1983 Abstract

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