Last update May 22, 2023
Very Low Risk
It is a class Ib antiarrhythmic with actions and structure similar to that of lidocaine. Indicated in ventricular arrhythmias and non-dystrophic myotonias. Oral or intravenous administration.
It is excreted in breast milk in clinically insignificant amounts. (Monfort 2021 & 2019, Lewis 1981, Timmis 1980)
No problems have been observed in nursing infants of mothers treated with Mexiletine (Monfort 2023, Lownes 1987, Gregg 1988, Timmis 1980), except for excessive weight loss at 17 days in a low-weight newborn whose mother was also taking atenolol and which was resolved with maternal education and formula supplementation. (Lownes 1987)
Plasma levels in these infants were undetectable. (Timmis 1980)
Expert authors consider the use of monoclonal antibodies to be safe during breastfeeding. (Hale, Briggs 2015)
American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)
We do not have alternatives for Mexiletine since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Confederación Nacional de Pediatría (CONAPEME) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM