Last update Feb. 27, 2014


High Risk

Poorly safe. Evaluate carefully. Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives). Read the Comment.

Milnacipran active enantiomer.

Serotonin and Norepinephrine selective re-uptake inhibitor antidepressant drug. Frequent and potential severe side effects have been found.

Latest update failed to find relevant data on breastfeeding.

Pharmacokinetic data (low serum protein binding and high bioavailability) indicates that drug excretion into breast milk in significant amount is highly probable. Absorption by the infant is likely to be high as well.

A known alternative would be preferred until more information on the drug is available.


  • Duloxetine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Paroxetine ( Safe. Compatible. Minimal risk for breastfeeding and infant.)
  • Sertraline Hydrochloride ( Safe. Compatible. Minimal risk for breastfeeding and infant.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Levomilnacipran belongs to this group or family:


Main tradenames from several countries containing Levomilnacipran in its composition:


Variable Value Unit
Oral Bioavail. 92 %
Molecular weight 283 daltons
Protein Binding 22 %
VD 5.5 - 6.7 l/Kg
Tmax 6 - 8 hours
12 (10 - 20) hours


  1. Levomilnacipran. Drug summary. 2013 Full text (in our servers)

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