Last update Aug. 21, 2016

Erythromycin (topical use)

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

La pequeña dosis y la escasa absorción plasmática de la mayoría de preparaciones dermatológicas u oftalmológicas tópicas hacen poco probable el paso de cantidad significativa a leche materna.

No aplicar sobre el pecho para evitar que el lactante lo ingiera; caso necesario, aplicar tras una toma y limpiar bien con agua antes de la próxima.

Conviene evitar la aplicación sobre el pezón de cremas, geles y otros producto de aplicación local que contengan parafina (aceite mineral) para que el lactante no lo absorba.

Academia Americana de Pediatría: medicación usualmente compatible con la lactancia.

Listado de medicamentos esenciales OMS 2002: compatible con la lactancia.


We do not have alternatives for Erythromycin (topical use) since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Erythromycin (topical use) in other languages or writings:


Erythromycin (topical use) belongs to this group or family:


Main tradenames from several countries containing Erythromycin (topical use) in its composition:


Variable Value Unit
Oral Bioavail. 0 (cutánea) %
Molecular weight 734 daltons
Protein Binding 70 - 95 %
Tmax 1 - 4 hours
1.5 - 2.5 hours
M/P ratio 0.9 - 1.6 -
Theoretical Dose 0 mg/Kg/d
Relative Dose 0 %


  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013 Jun;73(8):779-87. Abstract
  3. Fluhr JW, Degitz K. [Antibiotics, azelaic acid and benzoyl peroxide in topical acne therapy]. J Dtsch Dermatol Ges. 2010 Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Worret WI, Fluhr JW. [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. J Dtsch Dermatol Ges. 2006 Abstract
  6. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract

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e-lactancia is a resource recommended by AELAMA of Spain

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