Last update Aug. 26, 2017

Ephedrine Topical Use

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It has been used as complementary drug for local anesthesia, on compounds for dermatology or oral surgical procedures.

Since the last update we have not found published data on its excretion in breast milk.

They are harmless when properly used. Absorption is almost nil (AEMPS 2008).

Avoid applying it on the breast, otherwise, cleanse the area thoroughly and/or do it after having nursed.

List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).


We do not have alternatives for Ephedrine Topical Use since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Main tradenames from several countries containing Ephedrine Topical Use in its composition:

  • Hemoal™. Contains other elements than Ephedrine Topical Use in its composition


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 165 daltons
3 - 6 hours


  1. AEMPS Hemoal (Benzocaína + Efedrina). Ficha técnica. 2008 Full text (in our servers)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain

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