Last update Sept. 28, 2014

デキシブプロフェン

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

On latest update no published data about breastfeeding were found. However, it is an enantiomer of Ibuprofen with similar pharmacokinetic properties. Ibuprofen has not been detected or only in very tiny amounts in the breast milk.

Because of a high plasma protein binding capacity, excretion into breast milk seems to be unlikely.

Alternatives

We do not have alternatives for デキシブプロフェン since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

デキシブプロフェン is also known as Dexibuprofen. Here it is a list of alternative known names::


Group

デキシブプロフェン belongs to this group or family:

Tradenames

Main tradenames from several countries containing デキシブプロフェン in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 95 %
Molecular weight 206 daltons
Protein Binding 99 %
Tmax 2.2 hours
T½ 1.8 - 3.5 hours

References

  1. Worthington I, Pringsheim T, Gawel MJ, Gladstone J, Cooper P, Dilli E, Aube M, Leroux E, Becker WJ; Canadian Headache Society Acute Migraine Treatment Guideline Development Group. Canadian Headache Society Guideline: acute drug therapy for migraine headache. Can J Neurol Sci. 2013 Sep;40(5 Suppl 3):S1-S80. Review. Abstract Full text (in our servers)
  2. Hutchinson S, Marmura MJ, Calhoun A, Lucas S, Silberstein S, Peterlin BL. Use of common migraine treatments in breast-feeding women: a summary of recommendations. Headache. 2013 Abstract Full text (link to original source) Full text (in our servers)
  3. Muralidharan S. Pharmacokinetic-pharmacodynamic model of newly developed dexibuprofen sustained release formulations. ISRN Pharm. 2012 Abstract Full text (link to original source) Full text (in our servers)
  4. Yoon JS, Jeong DC, Oh JW, Lee KY, Lee HS, Koh YY, Kim JT, Kang JH, Lee JS. The effects and safety of dexibuprofen compared with ibuprofen in febrile children caused by upper respiratory tract infection. Br J Clin Pharmacol. 2008 Abstract
  5. Sádaba B, Campanero MA, Muñoz-Juarez MJ, Gil-Aldea I, García-Quetglas E, Esteras A, Azanza JR. A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers. Eur J Clin Pharmacol. 2006 Abstract
  6. Medicines.org.uk. Dexibuprofen. Drug Summary. 2005 Full text (in our servers)
  7. MSyC-AEMPS. Dexibuprofeno. Ficha técnica. 2000 Full text (in our servers)
  8. Mitchell JL. Use of cough and cold preparations during breastfeeding. J Hum Lact. 1999 Abstract
  9. Eller N, Kollenz CJ, Schiel H, Kikuta C, Mascher H. Pharmacokinetics of dexibuprofen administered as 200 mg and 400 mg film-coated tablets in healthy volunteers. Int J Clin Pharmacol Ther. 1998 Abstract
  10. Walter K, Dilger C. Ibuprofen in human milk. Br J Clin Pharmacol. 1997 Abstract
  11. Albert KS, Gernaat CM. Pharmacokinetics of ibuprofen. Am J Med. 1984 Abstract
  12. Townsend RJ, Benedetti TJ, Erickson SH, Cengiz C, Gillespie WR, Gschwend J, Albert KS. Excretion of ibuprofen into breast milk. Am J Obstet Gynecol. 1984 Abstract
  13. Weibert RT, Townsend RJ, Kaiser DG, Naylor AJ. Lack of ibuprofen secretion into human milk. Clin Pharm. 1982 Abstract

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