Last update Oct. 15, 2016

Cefradine

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

First-generation cephalosporin for oral and injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Mischler 1978).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefradine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Cefradine is also known as


Cefradine in other languages or writings:

Group

Cefradine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefradine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 349 daltons
Protein Binding 8 - 12 %
VD 0.29 l/Kg
Tmax 1 hours
T½ 2 hours
M/P ratio 1 -
Theoretical Dose 0.2 mg/Kg/d
Relative Dose 1.2 %
Ped.Relat.Dose 0.4 %

References

  1. Jahanfar S, Ng CJ, Teng CL. Antibiotics for mastitis in breastfeeding women. Cochrane Database Syst Rev. 2013 Feb 28; Abstract Full text (link to original source)
  2. Cabou A, Babineau S, St Anna L. Clinical inquiry: what's the best way to relieve mastitis in breastfeeding mothers? J Fam Pract. 2011 Abstract Full text (in our servers)
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Mischler TW, Corson SL, Larranaga A, Bolognese RJ, Neiss ES, Vukovich RA. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978 Abstract

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