Last update July 17, 2014

Apazone

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

It is excreted into breast milk in very small amount. No adverse effects have been observed in infants.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for Apazone since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.
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Other names

Apazone is also known as Azapropazone. Here it is a list of alternative known names::


Group

Apazone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Apazone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 83 %
Molecular weight 300 daltons
Protein Binding 99 %
VD 0.17 l/Kg
Tmax 3 - 6 hours
T½ 13 - 14 hours
Theoretical Dose 0.4 mg/Kg/d
Relative Dose 2 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Bald R, Bernbeck-Betthäuser EM, Spahn H, Mutschler E. Excretion of azapropazone in human breast milk. Eur J Clin Pharmacol. 1990 Abstract
  3. Breuing KH, Gilfrich HJ, Meinertz T, Jähnchen E. Pharmacokinetics of azapropazone following single oral and intravenous doses. Arzneimittelforschung. 1979 Abstract

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