Last update July 24, 2014

Amikin

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Levels in the mother's milk are very low and in most instances undetectable.

Like other aminoglycosides it is poorly absorbed in the intestine.

Large doses may affect intestinal flora.

Be aware of false negative bacterial cultures in the infant when the mother is on antibiotics.

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Alternatives

We do not have alternatives for Amikin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Amikin is also known as Amikacin.


Group

Amikin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Amikin in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 586 daltons
Protein Binding < 11 %
VD 0.3 l/Kg
Tmax 1 - 2 hours
T½ 2 - 3 hours
Theoretical Dose 0.25 mg/Kg/d
Relative Dose 1.7 %
Ped.Relat.Dose 1.7 %

References

  1. Baquero-Artigao F, Mellado Peña MJ, del Rosal Rabes T, Noguera Julián A, Goncé Mellgren A, de la Calle Fernández-Miranda M, Navarro Gómez ML; Working Group on gestational, congenital, and postnatal tuberculosis, Spanish Society of Pediatric Infectious Diseases (PFIC). Guía de la Sociedad Española de Infectología Pediátrica sobre tuberculosis en la embarazada y el recién nacido (ii): profilaxis y tratamiento. [Spanish Society for Pediatric Infectious Diseases guidelines on tuberculosis in pregnant women and neonates (ii): Prophylaxis and treatment]. An Pediatr (Barc). 2015 Abstract Full text (link to original source) Full text (in our servers)
  2. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  3. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984;5(2):57-60. Abstract
  5. Yuasa M. [Evaluation of amikacin in gynecological and obstetric field (author's transl)]. Jpn J Antibiot. 1974 Abstract
  6. Matsuda S, Mori S, Tanno M, Kashiwagura T. [Evaluation of amikacin in obstetric and gynecological fields (author's transl)]. Jpn J Antibiot. 1974 Abstract

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