Last update: Oct. 28, 2014

Varenicline

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

It is a nicotine receptor agonist, which is specifically used for quitting from the tobacco smoking habit. There is not published information available on the use of this drug while nursing.

Because of pharmacokinetic characteristics its appearance in breastmilk is very likely.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Varenicline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Varenicline in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 361 daltons
Protein Binding 20 %
Tmax 4 hours
T1/2 24 hours

References

  1. Baraona LK, Lovelace D, Daniels JL, McDaniel L. Tobacco Harms, Nicotine Pharmacology, and Pharmacologic Tobacco Cessation Interventions for Women. J Midwifery Womens Health. 2017 Abstract
  2. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  3. Carson KV, Brinn MP, Robertson TA, To-A-Nan R, Esterman AJ, Peters M, Smith BJ. Current and emerging pharmacotherapeutic options for smoking cessation. Subst Abuse. 2013 Abstract Full text (link to original source) Full text (in our servers)

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