Last update: Dec. 8, 2017


Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

A 5-phosphodiesterase inhibitor with uses similar to sildenafil, used in the treatment of pulmonary hypertension (including in children: Takatsuki 2012), erectile dysfunction in men, Raynaud's syndrome and in other treatments due to its vasodilatory effect on smooth muscle.

Since the last update, we have not found published data on its excretion in breast milk.

Its high percentage of protein binding makes it unlikely that it will be transferred to milk in significant amounts, as in fact has been seen in another drug from the same therapeutic group, sildenafil.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tadalafil in other languages or writings:


Main tradenames from several countries containing Tadalafil in its composition:


Variable Value Unit
Molecular weight 389 daltons
Protein Binding 94 %
VD 0,9 - 1,1 l/Kg
Tmax 2 (1 - 4) hours
T1/2 17,5 hours


  1. EMA. Tadalafilo. Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Tadalafil. Drug Summary. 2017 Full text (in our servers)
  3. Takatsuki S, Calderbank M, Ivy DD. Initial experience with tadalafil in pediatric pulmonary arterial hypertension. Pediatr Cardiol. 2012 Abstract Full text (link to original source)
  4. Forgue ST, Patterson BE, Bedding AW, Payne CD, Phillips DL, Wrishko RE, Mitchell MI. Tadalafil pharmacokinetics in healthy subjects. Br J Clin Pharmacol. 2006 Abstract Full text (link to original source)

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