Last update: July 31, 2018

Silodosin

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Alpha-1 adrenergic blocker indicated in benign prostatic hyperplasia (BPH) in adult males.
Oral administration once a day.

Since the last update we have not found published data on its excretion in breastmilk.

Its high percentage of protein binding (EMA 2018) makes transfer into milk in significant amounts unlikely.

Its low oral bioavailability, reduced further with the consumption of fatty foods, such as milk (EMA 2018), hinders its transfer to the infant’s plasma from the breastmilk ingested, except in premature babies and the immediate neonatal period when there may be greater intestinal permeability.

Possible side effects are not serious or frequent (EMA 2018).

Alternatives

We do not have alternatives for Silodosin.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Silodosin is also known as


Silodosin in other languages or writings:

Tradenames

Main tradenames from several countries containing Silodosin in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 32 %
Molecular weight 496 daltons
Protein Binding 96,6 %
VD 0,81 l/Kg
pKa 14,9 -
Tmax 2,5 ( 1 - 3 ) hours
T1/2 11 - 24 hours

References

  1. EMA. Silodosin. Drug Summary. 2018 Full text (in our servers)
  2. EMA. Silodosina. Ficha técnica. 2018 Full text (in our servers)

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