Last update: Dec. 8, 2017

Sildenafil

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

A 5-phosphodiesterase inhibitor used in the treatment of pulmonary hypertension, erectile dysfunction in men, Raynaud's syndrome and in other treatments due to its vasodilatory effect on smooth muscle.

Its use is authorized in small infants and neonates to treat pulmonary hypertension (Lakshminrusimha 2016, Krishnan 2010).

Sildenafil and its metabolite N-desmethylsildenafil are excreted in breast milk in clinically insignificant amounts, much lower than the dose used in newborns and infants (Wollein 2016).

Alternatives

We do not have alternatives for Sildenafil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Sildenafil in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 41 (25 - 63) %
Molecular weight 667 daltons
Protein Binding 96 %
VD 1,5 l/Kg
Tmax 1 (0,5 - 2) hours
T1/2 4 (3 - 5) hours
Theoretical Dose 0,00067 mg/Kg/d
Relative Dose 0,042 %

References

  1. Wollein U, Schech B, Hardt J, Schramek N. Determination and quantitation of sildenafil and its major metabolite in the breast milk of a lactating woman. J Pharm Biomed Anal. 2016 Abstract
  2. Lakshminrusimha S, Mathew B, Leach CL. Pharmacologic strategies in neonatal pulmonary hypertension other than nitric oxide. Semin Perinatol. 2016 Abstract
  3. EMA. Sildenafilo. Ficha técnica. 2016 Full text (in our servers)
  4. EMA. Sildenafil. Drug Summary. 2016 Full text (in our servers)
  5. Krishnan U. Management of pulmonary arterial hypertension in the neonatal unit. Cardiol Rev. 2010 Abstract

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