Last update: July 2, 2015

Sibutramine

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

On latest update relevant published data on breastfeeding were not found.

Because of high protein-binding, excretion into breast milk seems unlikely.

Medication used as anorexigen. Amphetamine-like drug that acts as reuptake inhibitor of Serotonin, Norepinephrine and Dopamine. May cause increase of Prolactin and Galactorrhea.

Because of cardiovascular side effects (Arrhythmia, Hypertension, Heart infarction) several regulatory agencies (EMEA, FDA) have withdrawn it from the market in many countries.

Breastfeeding mothers return to their pre- pregnancy body weight sooner than others who don't.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Sibutramine in other languages or writings:

Group

Sibutramine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Sibutramine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 77 %
Molecular weight 334 daltons
Protein Binding 94 - 97 %
Tmax 1 - 3 hours
T1/2 1 - 16 hours

References

  1. Soares Leaes CG, Pereira-Lima JF, da Costa Oliveira M. A case of sibutramine-induced hyperprolactinemia. Neuro Endocrinol Lett. 2011 Abstract
  2. EMEA. European Medicines Agency recommends suspension of marketing authorisations for sibutramine. Press Office. 2010 Full text (link to original source) Full text (in our servers)
  3. FDA. FDA Recommends Against the Continued Use of Meridia (sibutramine). FDA Drug Safety Communication. 2010 Full text (link to original source) Full text (in our servers)
  4. MHRA (UK). Sibutramine: Suspension of marketing authorisation as risks outweigh benefits. Safety warnings and messages for medicines. 2010 Full text (link to original source) Full text (in our servers)
  5. Florakis D, Diamanti-Kandarakis E, Katsikis I, Nassis GP, Karkanaki A, Georgopoulos N, Panidis D. Effect of hypocaloric diet plus sibutramine treatment on hormonal and metabolic features in overweight and obese women with polycystic ovary syndrome: a randomized, 24-week study. Int J Obes (Lond). 2008 Abstract Full text (link to original source) Full text (in our servers)
  6. Sibutramina. Ficha técnica. 2000 Full text (in our servers)
  7. Sibutramine. Drug Summary. 2000 Full text (in our servers)

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