Last update: July 20, 2017
Not risky for breastfeeding or infant.
Piperacillin (see specific info) is a ureidopenicillin similar to ticarcillin (see specific info).
Tazobactam is added as a beta-lactamase inhibitor with few clinical and pharmacokinetic effects similar to that of piperacillin.
It is excreted into breastmilk in a clinically insignificant amount (Baier 1982, Chaplin 1982, Wyeth 2007).
Because it lacks of oral bioavailability, seems difficult any pass to the infant’s plasma through the breast milk ingested, except on premature infants and immediate neonatal period, in which there may be an increased intestinal permeability.
Authorized use in infants and small infants (Chen 2009).
Be aware of the likelihood of false negative cultures of febrile infants whose mothers are on antibiotics, as well as the possibility of gastroenteritis due to imbalanced intestinal flora.
We do not have alternatives for Piperacillin + Tazobactam since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
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