Last update: July 5, 2014

PAS

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Drug related to same group of 5-aminosalicylic Acid

It is excreted in tiny amounts into breast milk with no reported cases of harm effects except a case of mild gastroenteritis.

Alternatives

We do not have alternatives for PAS since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

PAS is also known as Paraminosalicylic Acid. Here it is a list of alternative known names::


Group

PAS belongs to this group or family:

Tradenames

Main tradenames from several countries containing PAS in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability > 90 %
Molecular weight 153 daltons
Protein Binding 50 - 70 %
Tmax 1 - 4 hours
T1/2 1 hours
M/P ratio 0,1 - 0,2 -
Theoretical Dose 0,15 mg/Kg/d
Relative Dose 0,1 %
Relat.Ped.Dose 0,01 - 0,1 %

References

  1. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  2. Silverman DA, Ford J, Shaw I, Probert CS. Is mesalazine really safe for use in breastfeeding mothers? Gut. 2005 Abstract Full text (link to original source) Full text (in our servers)
  3. Drobac PC, del Castillo H, Sweetland A, Anca G, Joseph JK, Furin J, Shin S. Treatment of multidrug-resistant tuberculosis during pregnancy: long-term follow-up of 6 children with intrauterine exposure to second-line agents. Clin Infect Dis. 2005 Abstract Full text (link to original source) Full text (in our servers)
  4. Jenss H, Weber P, Hartmann F. 5-Aminosalicylic acid and its metabolite in breast milk during lactation. Am J Gastroenterol. 1990 Abstract
  5. Nelis GF. Diarrhoea due to 5-aminosalicylic acid in breast milk. Lancet. 1989 Abstract
  6. Holdiness MR. Antituberculosis drugs and breast-feeding. Arch Intern Med. 1984 Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by La Liga de la Leche de Euskadi

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