Last update: Nov. 4, 2018

Nitazoxanide

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

An antiprotozoal used in the treatment of cryptosporidiosis, giardiasis, intestinal amebiasis, blastocystosis, cutaneous leishmaniasis and microsporidiosis.
Oral administration twice a day for 3 days.

Its pharmacokinetic data - extremely high percentage of protein binding (MK 2014, FDA 2005) and short half-life (Stocks 1996) - explain the negligible transfer to breastmilk observed (Hadad 2012).

Its use is authorized in children from one year of age (Committee 2015, FDA 2005).
Possible side effects are not frequent or serious (abdominal pain, diarrhea, vomiting, headache).

Several experts consider its use to be safe during breastfeeding (Hale 2017 p 710, Briggs 2017, Lactmed 2013).

Alternatives

We do not have alternatives for Nitazoxanide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Nitazoxanide in other languages or writings:

Group

Nitazoxanide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Nitazoxanide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 %
Molecular weight 307 daltons
Protein Binding > 99 %
Tmax 1 - 4 hours
T1/2 1,03 - 1,6 hours
Theoretical Dose 0,21 mg/Kg/d
Relative Dose 1,2 %
Relat.Ped.Dose 1,4 %

References

  1. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Comité de Medicamentos de la Asociación Española de Pediatría. Nitazoxanida. Pediamécum.. 2015 Full text (link to original source) Full text (in our servers)
  4. MK. Nitazoxanida. Ficha técnica. 2014 Full text (in our servers)
  5. Hadad GM, Abdel Salam RA, Emara S. Validated and optimized high-performance liquid chromatographic determination of tizoxanide, the main active metabolite of nitazoxanide in human urine, plasma and breast milk. J Chromatogr Sci. 2012 Abstract Full text (link to original source) Full text (in our servers)
  6. Unipharm. NItazoxanida. Ficha técnica. 2009 Full text (in our servers)
  7. FDA-Romark. Nitazoxanide. Drug Summary. 2005 Full text (in our servers)
  8. Stockis A, Deroubaix X, Lins R, Jeanbaptiste B, Calderon P, Rossignol JF. Pharmacokinetics of nitazoxanide after single oral dose administration in 6 healthy volunteers. Int J Clin Pharmacol Ther. 1996 Abstract

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