Last update: Dec. 8, 2017

(±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

An anti-enkephalin that decreases intestinal secretion.

Since the latest update, we have not found published data on its excretion in breast milk.

Its high percentage of protein binding makes it unlikely it will transfer to milk in significant quantities.

Possible side effects are not serious or frequent.

Its use is authorized in infants from 3 months of age (Pediamecum 2015)

Its indiscriminate use in treating gastroenteritis is not justified. Most cases of gastroenteritis do not require medication: good hydration is sufficient, even more so in the case of a breastfeeding mother.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

(±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate is Racecadotril in Chemical name.

Is written in other languages:

(±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate is also known as

Group

(±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate belongs to this group or family:

Tradenames

Main tradenames from several countries containing (±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate in its composition:

  • Aidia™. Contains other elements than (±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate in its composition
  • Dotvil™. Contains other elements than (±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate in its composition
  • Editor™. Contains other elements than (±)-N-{2-[(Acetylthio)methyl]-1-oxo-3-phenylpropyl}glycine phenylmethyl ester; N-[(R,S)-3-acetylthio-2-benzylpropanoyl]glycine benzyl ester; (±)-N-[α-(Mercaptomethyl)hydrocinnamoyl]glycine benzyl ester acetate in its composition
  • Hidrasec (海兰赛)
  • Hydrasek (Гидрасек)
  • Mo Ni Ka (莫尼卡)
  • Tiorfan
  • Tiorfast
  • Tiorfix

Pharmacokinetics

Variable Value Unit
Molecular weight 386 daltons
Protein Binding 90 %
Tmax 2 hours
T1/2 3 hours

References

  1. AEMPS. Racecadotrilo. Ficha técnica. 2017 Full text (in our servers)
  2. Comité de Medicamentos de la Asociación Española de Pediatría. Racecadotrilo. Pediamécum. 2015 Full text (in our servers)
  3. MRI Index. Racecadotril. Drug Summary. 2007 Full text (in our servers)

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