Last update: July 31, 2016

Methylprednisolone Sodium Succinate

Very Low Risk for breastfeeding

Not risky for breastfeeding or infant.

Excreted into breast milk in non-significant amount with no problems reported in breastfed infants whose mothers were treated at a daily dose as high as 8 mg for a long time period.

On long term treatments it would be advisable to wait for 2 - 4 hours until the next nurse to minimize the transfer of drug to breast milk. By waiting for 2 a 4 hours after a methylprednisolone megadose or a pulse therapy dose, the transfer into breast milk may be minimized as well.

At high doses, intra-articular treatment with other steroid drugs (Triamcinolone) have transiently affected milk production. Steroids administered before delivery may delay initiation of phase II of Lactogenesis ("milk come in") and decrease milk production in the first postpartum week.

Decreased production has been seen while taking Dexametasone.

Steroid drugs are commonly used for Pediatric treatment with no side effects when infrequently used and for short-time periods.

The American Academy of Pediatrics rates it compatible with breastfeeding.

WHO Model List of Essential Medicines (2002) rates it compatible with breastfeeding


We do not have alternatives for Methylprednisolone Sodium Succinate since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methylprednisolone Sodium Succinate is also known as Methylprednisolone. Here it is a list of alternative known names::

Methylprednisolone Sodium Succinate in other languages or writings:


Methylprednisolone Sodium Succinate belongs to this group or family:


Main tradenames from several countries containing Methylprednisolone Sodium Succinate in its composition:


Variable Value Unit
Bioavailability 80 %
Molecular weight 375 daltons
Protein Binding 62 %
VD 1,2 - 1,5 l/Kg
Tmax 2 hours
T1/2 3,5 - 8 hours
Theoretical Dose 0,2 mg/Kg/d
Relative Dose 1,45 %


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