Last update: Sept. 2, 2017

Metamfetamine Hydrochloride

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding several T½.
Read the Comment.

A sympathomimetic drug, powerful stimulant of the central nervous system, whose action and uses are similar to dextroamphetamine. It has been used in the treatment of Attention Deficit Hyperactivity Disorder (ADHD), but above all it is considered an illegal drug (Chomchai, 2016; Bartu, 2009). It is partially metabolized to amphetamine and is highly addictive.

It is excreted in breast milk (Chomchai, 2016; Bartu, 2009), with a slower elimination than in plasma, as the half-life in milk is 40 hours, disappearing completely from the milk 1 day before the values ​​in urine are negative (Chomchai, 2016).

In order to avoid exposure to the infant, it is estimated that 48 hours (Bartu, 2009) to 100 hours (Chomchai, 2016) should pass after the last use of methamphetamine before breastfeeding or, more safely, when the detection in the mother's urine is negative (Chomchai, 2016).

A breastfeeding mother who inhaled methamphetamine was accused of the cot death of her 2-month-old baby, although there has been some question as to whether methamphetamine in milk was the cause (Green, 1996; Ariagno, 1995).

There is little information on the impact of amphetamine abuse on infant development and health (Oei, 2012), but it is known that they are more exposed to social problems, domestic violence, and lower rates of breastfeeding (Shah, 2012, Oei, 2010).

Amphetamines do not cause significant decreases in prolactin levels (DeLeo, 1983). Methamphetamine withdrawal caused increased prolactin secretion (Zorick, 2011).

Its use as an illegal drug is totally discouraged (Oei, 2012).


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Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Groups

Metamfetamine Hydrochloride belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Metamfetamine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 64 - 70 %
Molecular weight 186 daltons
Tmax 5 - 6 hours
T1/2 4 - 16 hours
Theoretical Dose 0,02 - 0,05 mg/Kg/d

References

  1. Chomchai C, Chomchai S, Kitsommart R. Transfer of Methamphetamine (MA) into Breast Milk and Urine of Postpartum Women who Smoked MA Tablets during Pregnancy: Implications for Initiation of Breastfeeding. J Hum Lact. 2016 Abstract
  2. Oei JL, Kingsbury A, Dhawan A, Burns L, Feller JM, Clews S, Falconer J, Abdel-Latif ME. Amphetamines, the pregnant woman and her children: a review. J Perinatol. 2012 Abstract Full text (link to original source) Full text (in our servers)
  3. Shah R, Diaz SD, Arria A, LaGasse LL, Derauf C, Newman E, Smith LM, Huestis MA, Haning W, Strauss A, Della Grotta S, Dansereau LM, Roberts MB, Neal C, Lester BM. Prenatal methamphetamine exposure and short-term maternal and infant medical outcomes. Am J Perinatol. 2012 Abstract
  4. Zorick T, Mandelkern MA, Lee B, Wong ML, Miotto K, Shabazian J, London ED. Elevated plasma prolactin in abstinent methamphetamine-dependent subjects. Am J Drug Alcohol Abuse. 2011 Abstract
  5. Oei J, Abdel-Latif ME, Clark R, Craig F, Lui K. Short-term outcomes of mothers and infants exposed to antenatal amphetamines. Arch Dis Child Fetal Neonatal Ed. 2010 Abstract
  6. Bartu A, Dusci LJ, Ilett KF. Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine. Br J Clin Pharmacol. 2009 Abstract Full text (link to original source) Full text (in our servers)
  7. Green LS. People v Henderson: the prosecution responds. JAMA. 1996 Abstract
  8. Ariagno R, Karch SB, Middleberg R, Stephens BG, Valdès-Dapena M. Methamphetamine ingestion by a breast-feeding mother and her infant's death: People v Henderson. JAMA. 1995 Abstract
  9. DeLeo V, Cella SG, Camanni F, Genazzani AR, Müller EE. Prolactin lowering effect of amphetamine in normoprolactinemic subjects and in physiological and pathological hyperprolactinemia. Horm Metab Res. 1983 Abstract

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