Last update: Jan. 12, 2015

グアイフェネシン

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

It is used as an expectorant, alone or in association with other products. Proofs on its effectiveness are sparse. In some instances, preparations of Guaifenesin may contain alcohol as excipient with a concentration as high as 5%.

At latest update, relevant published data on excretion into breast milk were not found.

Until more information on this medication is available, other option known to be safer would be recommended, mostly in the post-natal period or in cases of prematurity.

If used while breastfeeding, a moderate use with the lowest dose as possible and avoiding those preparations with alcoholic excipient, should be preferred.

Because effectiveness is poor and likelihood of side effects does exist, especially in multi-association, the US Agency for Drug Administration (FDA) is currently doing efforts for discontinuation of this and others at-the-counter products, that are formulated for cough relief (Guaifenesin, Dextromethorphan, Phenylephrine, Pseudoephedrine, Brompheniramine, etc.)

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

グアイフェネシン is also known as Guaifenesin. Here it is a list of alternative known names::


Group

グアイフェネシン belongs to this group or family:

Tradenames

Main tradenames from several countries containing グアイフェネシン in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 198 daltons
Tmax 0,25 hours
T1/2 1 hours

References

  1. Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014 Abstract
  2. AEMPS. Guaifenesina. Ficha técnica. 2013 Full text (in our servers)
  3. Guaifenesin. Drug Summary. 2012 Full text (in our servers)
  4. REis AMM, Figueras A. Analysis of the evidence of efficacy and safety of over-the-counter cough medications registered in Brazil. Brazilian Journal of Pharmaceutical Sciences, 46: 1. 2010 Full text (in our servers)
  5. Bolser DC. Cough suppressant and pharmacologic protussive therapy: ACCP evidence-based clinical practice guidelines. Chest. 2006 Abstract Full text (link to original source) Full text (in our servers)
  6. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract

Total visits

1,250

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write to us at elactancia.org@gmail.com

e-lactancia is a resource recommended by IHAN from Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM