Last update: May 31, 2019

Gentamicin

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

ue presets urticaria transitoria Excreted into breast milk in non-significant amount. Harmful effect has not been shown in breastfed infants whose mothers were treated with Gentamicin, except on case of a child who presented with bloody stools while the mother was receiving Gentamicin and Clindamycin.

Low intestinal absorption leads to low or nil concentration in blood serum, with exception of premature infants or early neonatal period in which higher absorption may occur.

Consider the possibility of false negative results of bacterial cultures among febrile breastfed infants whose mothers are treated with Gentamicin. Gastroenteritis due to intestinal flora imbalance is also likely.

When eye drops are used like many other topical ophtalmologic preparations that use low doses with scanty excretion into serum are considered to be compatible with breastfeeding.

The American Academy of Pediatrics rates it compatible with breastfeeding.

The WHO Model List of Essential Medicines 2002 rates it as compatible with breastfeeding.

Alternatives

We do not have alternatives for Gentamicin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Gentamicin is also known as


Gentamicin in other languages or writings:

Groups

Gentamicin belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Gentamicin in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability < 1 %
Molecular weight 478 daltons
Protein Binding < 30 %
VD 0,2 - 0,4 l/Kg
Tmax 0,5 - 1,5 hours
T1/2 2 - 3 hours
M/P ratio 0,1 - 0,4 -
Theoretical Dose 0,07 mg/Kg/d
Relative Dose 1 . 1,7 %
Relat.Ped.Dose 2,8 %

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  4. Arbex MA, Varella Mde C, Siqueira HR, Mello FA. Antituberculosis drugs: drug interactions, adverse effects, and use in special situations. Part 2: second line drugs. J Bras Pneumol. 2010 Abstract Full text (link to original source) Full text (in our servers)
  5. Cherif F, El Aidli S, Kastalli S, Zaiem A, Daghfous Moula H, Lakhal M, Daghfous R. Drug induced urticaria via breastfeeding. in; Abstracts of the 13th Annual Meeting of French Society of Pharmacology and Therapeutics, 76th Annual Meeting of Society of Physiology, 30th Pharmacovigilance Meeting, 10th APNET Seminar and 7th CHU CIC Meeting, 15‐17 April 2009, Marseille, France Fundam Clin Pharmacol. 2009;23 (Suppl 1):37. Abstract 203
  6. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007
  7. Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006 Jul;131(1):283-311. Review. Abstract Full text (link to original source) Full text (in our servers)
  8. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol. 2006 Abstract
  9. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  10. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  11. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  12. Celiloglu M, Celiker S, Guven H, Tuncok Y, Demir N, Erten O. Gentamicin excretion and uptake from breast milk by nursing infants. Obstet Gynecol. 1994 Abstract
  13. Fulton B, Moore LL. Antiinfectives in breastmilk. Part II: Sulfonamides, tetracyclines, macrolides, aminoglycosides and antimalarials. J Hum Lact. 1992 Dec;8(4):221-3. Review. No abstract available. Abstract
  14. Niebyl JR. Use of antibiotics for ear, nose, and throat disorders in pregnancy and lactation. Am J Otolaryngol. 1992 Jul-Aug;13(4):187-92. Review. No abstract available. Abstract
  15. Boda A. [Gentamycin concentration in the milk of a mother after treatment by implantation of a Septopal chain]. Orv Hetil. 1990 Abstract
  16. Mann CF. Clindamycin and breast-feeding. Pediatrics. 1980 Abstract
  17. Nelson JD, McCracken GH Jr. The current status of gentamicin for tne neonate and young infant. Am J Dis Child. 1972 Jul;124(1):13-4. No abstract available. Abstract
  18. Ito T. [Absorption, excretion and effects of gentamicin in newborn infants]. Jpn J Antibiot. 1970 Jun;23(3):298-311. Japanese. No abstract available. Abstract

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