Last update: March 17, 2019

Diazoxide

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

A drug with hyperglycemic and antihypertensive action via peripheral vasodilatation.
Indicated orally (2 to 3 daily doses) in the treatment of unresponsive hyperglycemia by hyperinsulinism and intravenously in hypertensive crises.
Its use is authorized in the neonatal and infant period.

Since the last update we have not found any published data on its excretion in breast milk.

According to the limited pharmacokinetic data available (Pfizer 2017, Merck 2015), its high plasma protein binding could impede transfer to breastmilk, but its prolonged half-life, which would facilitate it, makes it prudent that, until more information about this drug is published in relation to breastfeeding, safer known alternatives may be preferable (Schaefer 2007 p685), especially during the neonatal period and in case of prematurity.

To minimize risks of exposure, it would be necessary to wait 5 days after the last dose to restart breastfeeding. Meanwhile, express and discard breastmilk regularly to maintain production.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Diazoxide is Diazoxide in French.

Is written in other languages:

Tradenames

Main tradenames from several countries containing Diazoxide in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 231 daltons
Protein Binding 90 %
pKa 8,74 -
Tmax 0,1 hours
T1/2 28 ± 8.3 hours

References

  1. Pfizer. Diazoxide (injection). Drug Summary. 2017 Full text (in our servers)
  2. Merck. Diazoxide (oral). Drug Summary. 2015 Full text (in our servers)
  3. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007

Total visits

185

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