Last update: Nov. 5, 2014

Clindamycin-Vaginal

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Less than 10% of Clindamycin as cream and less than 30% as ovule reaches the blood plasma.

On the other hand, clindamycin is excreted in non-significant level intro breast milk with only few cases of enterocolitis due to disturbance of intestinal flora in breastfed infants who cured spontaneously after discontinuation of drug.

The American Academy of Pediatrics rates it as compatible with breastfeeding.

Alternatives

We do not have alternatives for Clindamycin-Vaginal since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Clindamycin-Vaginal in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 90 %
Molecular weight 425 daltons
Protein Binding 94 %
VD 2 l/Kg
Tmax 1 hours
T1/2 2,4 hours
M/P ratio 0,5 -
Theoretical Dose < 0,2 mg/Kg/d
Relative Dose < 0,6 %
Relat.Ped.Dose < 1 %

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  4. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  5. Borin MT, Ryan KK, Hopkins NK. Systemic absorption of clindamycin after intravaginal administration of clindamycin phosphate ovule or cream. J Clin Pharmacol. 1999 Abstract
  6. Borin MT, Powley GW, Tackwell KR, Batts DH. Absorption of clindamycin after intravaginal application of clindamycin phosphate 2% cream. J Antimicrob Chemother. 1995 Abstract
  7. Borin MT. Systemic absorption of clindamycin following intravaginal application of clindamycin phosphate 1% cream. J Clin Pharmacol. 1990 Abstract
  8. Stéen B, Rane A. Clindamycin passage into human milk. Br J Clin Pharmacol. 1982 Abstract Full text (link to original source) Full text (in our servers)
  9. Mann CF. Clindamycin and breast-feeding. Pediatrics. 1980 Abstract
  10. Smith JA, Morgan JR, Rachlis AR, Papsin FR. Clindamycin in human breast milk. Can Med Assoc J. 1975 Abstract Full text (in our servers)

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