Last update: Jan. 15, 2020

Clindamycin Topical

Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Lincosamide antibacterial. Anti-acne treatment drug.

Because a small dose and low plasma level found when topical preparations are used, locally applied products on skin do not have a significant excretion into breast milk. Less than 5% of the drug actually reach the blood plasma.

On the other hand, clindamycin is excreted in non-significant level intro breast milk with only few cases of enterocolitis in breastfed infants who cured spontaneously after discontinuation of drug.

Do not apply it on the breast or cleanse it thoroughly before nursing.

The American Academy of Pediatrics rates it as compatible with breastfeeding.

See below the information of this related product:


We do not have alternatives for Clindamycin Topical since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.


Main tradenames from several countries containing Clindamycin Topical in its composition:

  • Dalacin T
  • Duac™. Contains other elements than Clindamycin Topical in its composition
  • Retin-A Forte™. Contains other elements than Clindamycin Topical in its composition
  • Treclinac™. Contains other elements than Clindamycin Topical in its composition
  • Zindaclin


Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 425 daltons
Protein Binding 94 %
VD 2 l/Kg
Tmax 1 hours
T1/2 2,4 hours
M/P ratio 0,5 -
Theoretical Dose < 0,2 mg/Kg/d
Relative Dose < 0,6 %
Relat.Ped.Dose < 1 %


  1. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  2. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  3. Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013 Jun;73(8):779-87. Abstract
  4. Concin N, Hofstetter G, Plattner B, Tomovski C, Fiselier K, Gerritzen K, Fessler S, Windbichler G, Zeimet A, Ulmer H, Siegl H, Rieger K, Concin H, Grob K. Mineral oil paraffins in human body fat and milk. Food Chem Toxicol. 2008 Abstract
  5. Nahum GG, Uhl K, Kennedy DL. Antibiotic use in pregnancy and lactation: what is and is not known about teratogenic and toxic risks. Obstet Gynecol. 2006 Abstract
  6. Worret WI, Fluhr JW. [Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid]. J Dtsch Dermatol Ges. 2006 Abstract
  7. Noti A, Grob K, Biedermann M, Deiss U, Brüschweiler BJ. Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003 Abstract
  8. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  9. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  10. Chin KG, McPherson CE 3rd, Hoffman M, Kuchta A, Mactal-Haaf C. Use of anti-infective agents during lactation: Part 2--Aminoglycosides, macrolides, quinolones, sulfonamides, trimethoprim, tetracyclines, chloramphenicol, clindamycin, and metronidazole. J Hum Lact. 2001 Feb;17(1):54-65. Abstract
  11. Borin MT, Ryan KK, Hopkins NK. Systemic absorption of clindamycin after intravaginal administration of clindamycin phosphate ovule or cream. J Clin Pharmacol. 1999 Abstract
  12. van Hoogdalem EJ. Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol. 1998 Abstract
  13. Borin MT, Powley GW, Tackwell KR, Batts DH. Absorption of clindamycin after intravaginal application of clindamycin phosphate 2% cream. J Antimicrob Chemother. 1995 Abstract
  14. Borin MT. Systemic absorption of clindamycin following intravaginal application of clindamycin phosphate 1% cream. J Clin Pharmacol. 1990 Abstract
  15. Stéen B, Rane A. Clindamycin passage into human milk. Br J Clin Pharmacol. 1982 Abstract Full text (link to original source) Full text (in our servers)
  16. Mann CF. Clindamycin and breast-feeding. Pediatrics. 1980 Abstract
  17. Smith JA, Morgan JR, Rachlis AR, Papsin FR. Clindamycin in human breast milk. Can Med Assoc J. 1975 Abstract Full text (in our servers)
  18. Hale TW. Hale's Medications & Mothers' Milk. [Internet]. Springer Publishing Company; 1991-. Available from: None

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