Last update: Nov. 8, 2014

Chlortalidone

Very High Risk for breastfeeding


Very unsafe. Contraindicated.
Use of an alternative or cessation of breastfeeding.

Thiazidic diuretic. Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation. Use a lower dose as possible, especially during the first postnatal month.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Chlortalidone is also known as


Group

Chlortalidone belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chlortalidone in its composition:

  • Clorpres™. Contains other elements than Chlortalidone in its composition
  • Higroton
  • Higroton-Res™. Contains other elements than Chlortalidone in its composition
  • Higrotona
  • Hygroton
  • Igroton
  • Regroton™. Contains other elements than Chlortalidone in its composition
  • TRI-Normin™. Contains other elements than Chlortalidone in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 65 %
Molecular weight 339 daltons
Protein Binding 75 %
Tmax 6 hours
T1/2 60 hours
Theoretical Dose 0,13 mg/Kg/d
Relative Dose 26 %
Relat.Ped.Dose 13 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Ghanem FA, Movahed A. Use of antihypertensive drugs during pregnancy and lactation. Cardiovasc Ther. 2008 Abstract Full text (link to original source) Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)

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