Last update: May 11, 2019

Chlorhydrate de Térazosine

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

It is an alpha-1-adrenergic blocking agent that is used for treatment of arterial hypertension and of obstructive symptoms resulting from benign prostatic hypertrophy.
Oral administration once a day.

Since the last update we have not found any published data on its excretion in breast milk.

Its pharmacokinetic characteristics (moderately elevated molecular weight and high plasma protein binding and large volume of distribution, make it very unlikely its excretion into breast milk in significant amounts and its subsequent absorption by the infant.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable (Anderson 2018, Malachias 2016, Schaefer 2007 p685), especially during the neonatal period and in case of prematurity

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Chlorhydrate de Térazosine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 460 daltons
Protein Binding 94 %
pKa 7,24 -
Tmax 1 - 2 hours
T1/2 9 - 12 hours

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  3. KPh. Terazosina. Ficha técnica. 2013 Full text (in our servers)
  4. Terazosin. Drug Summary. 2010 Full text (in our servers)
  5. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007

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