Last update: Oct. 15, 2016

Cefradine

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

First-generation cephalosporin for oral and injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Mischler 1978).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefradine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefradine is also known as


Cefradine in other languages or writings:

Group

Cefradine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefradine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 349 daltons
Protein Binding 8 - 12 %
VD 0,29 l/Kg
Tmax 1 hours
T1/2 2 hours
M/P ratio 1 -
Theoretical Dose 0,2 mg/Kg/d
Relative Dose 1,2 %
Relat.Ped.Dose 0,4 %

References

  1. Cabou A, Babineau S, St Anna L. Clinical inquiry: what's the best way to relieve mastitis in breastfeeding mothers? J Fam Pract. 2011 Abstract Full text (in our servers)
  2. Jahanfar S, Ng CJ, Teng CL. Antibiotics for mastitis in breastfeeding women. Cochrane Database Syst Rev. 2009 Abstract
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Mischler TW, Corson SL, Larranaga A, Bolognese RJ, Neiss ES, Vukovich RA. Cephradine and epicillin in body fluids of lactating and pregnant women. J Reprod Med. 1978 Abstract

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