Last update: Oct. 15, 2016

Cefpodoxime Proxetil

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Third-generation cephalosporin for oral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (FDA 2013).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

It has been reported a case of hyperprolactinemia and galactorrhea (Khurana 2010).

Alternatives

We do not have alternatives for Cefpodoxime Proxetil since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefpodoxime Proxetil in other languages or writings:

Group

Cefpodoxime Proxetil belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefpodoxime Proxetil in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 50 %
Molecular weight 558 daltons
Protein Binding 22 - 40 %
VD 0,5 l/Kg
Tmax 2 - 3 hours
T1/2 2 - 3 hours
M/P ratio 0,16 -
Theoretical Dose 0,055 mg/Kg/d
Relative Dose 1,6 %
Relat.Ped.Dose 0,55 %

References

  1. FDA. Cefpodoxime. Drug Summary. 2013 Full text (in our servers)
  2. AEMPS. Cefpodoxima. Ficha técnica. 2012 Full text (in our servers)
  3. Khurana V, Gambhir IS. Cefpodoxime-induced hyperprolactinemic galactorrhea. Ann Intern Med. 2010 Abstract
  4. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  5. Saathoff N, Lode H, Neider K, Depperman KM, Borner K, Koeppe P. Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist. Antimicrob Agents Chemother. 1992 Abstract
  6. Tremblay D, Dupront A, Ho C, Coussediere D, Lenfant B. Pharmacokinetics of cefpodoxime in young and elderly volunteers after single doses. J Antimicrob Chemother. 1990 Abstract

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