Last update: Oct. 15, 2016

Cefotetan

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Second-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Cho 1982, Novelli 1983, Matsuda 1984).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefotetan since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefotetan in other languages or writings:

Group

Cefotetan belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefotetan in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability Baja - Poor %
Molecular weight 576 daltons
Protein Binding 76 - 91 %
VD 0,15 l/Kg
Tmax 1,5 - 3 hours
T1/2 3 - 4,6 hours
Theoretical Dose 0,04 - 0,08 mg/Kg/d
Relative Dose 0,3 - 0,6 %
Relat.Ped.Dose 0,1 - 0,25 %

References

  1. Martin C, Thomachot L, Albanese J. Clinical pharmacokinetics of cefotetan. Clin Pharmacokinet. 1994 Abstract
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  3. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  4. Matsuda S. Transfer of antibiotics into maternal milk. Biol Res Pregnancy Perinatol. 1984 Abstract
  5. Novelli A, Mazzei T, Ciuffi M et al. The penetration of intramuscular cefotetan disodium into human extra-vascular fluid and maternal milk secretion. Chemotherapy (Basel). 1983;2:337-42. 1983
  6. Cho N, Fukunaga K, Kuni K. Fundamental and clinical studies on cefotetan (YM09330) in the field of obstetrics and gynecology. Chemotherapy (Tokyo). 1982;30 (suppl 1):832-42. 1982

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e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece

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