Last update: Oct. 15, 2016

Cefalotin Sodium

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

First-generation cephalosporin for injection or parenteral administration.

Like most cephalosporins for which data are available, excretion occurs in breast milk in very small amount and it is clinically insignificant (Kafetzis 1981).

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

We do not have alternatives for Cefalotin Sodium since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefalotin Sodium is also known as


Cefalotin Sodium in other languages or writings:

Group

Cefalotin Sodium belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefalotin Sodium in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability Baja - Poor %
Molecular weight 418 daltons
Protein Binding 65 %
Tmax 0,5 hours
T1/2 0,8 hours
M/P ratio 0,6 -
Theoretical Dose 0,07 mg/Kg/d
Relative Dose 0,2 %
Relat.Ped.Dose 0,04 - 0,1 %

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Amir LH, Pirotta MV, Raval M. Breastfeeding--evidence based guidelines for the use of medicines. Aust Fam Physician. 2011 Abstract Full text (link to original source) Full text (in our servers)
  3. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  4. Fulton B, Moore LL. Antiinfectives in breastmilk. Part I: Penicillins and cephalosporins. J Hum Lact. 1992 Abstract
  5. Kafetzis DA, Siafas CA, Georgakopoulos PA, Papadatos CJ. Passage of cephalosporins and amoxicillin into the breast milk. Acta Paediatr Scand. 1981 Abstract

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