Last update: Oct. 28, 2014

Buprenorphine

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

It is a semi-synthetic opioid which is used to replace Methadone in the treatment of opioid addiction. Mothers on Buprenorphine showed a shorter mean hospital stay than those who were treated with Methadone.

The amount of dose reaching the infant is minimal and has no untoward side effects. It has been noticed a mild and transient abstinence syndrome after birth when sudden withdrawn occurred.

Addiction to narcotic drugs and the use of substitutive treatments lowers the breastfeeding rate and duration of nursing.

Alternatives

We do not have alternatives for Buprenorphine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Buprenorphine in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 31 %
Molecular weight 468 daltons
Protein Binding 96 %
Tmax 0,5 hours
T1/2 24 hours
M/P ratio 1,7 -
Theoretical Dose 0,0006 mg/Kg/d
Relative Dose 0,4 %

References

  1. Reece-Stremtan S, Marinelli KA. ABM Clinical Protocol #21: Guidelines for Breastfeeding and Substance Use or Substance Use Disorder, Revised 2015. Breastfeed Med. 2015 Abstract Full text (link to original source) Full text (in our servers)
  2. Lefevere J, Allegaert K. Question: is breastfeeding useful in the management of neonatal abstinence syndrome? Arch Dis Child. 2015 Abstract
  3. ABM Protocolo clínico de la ABM n.º 21: Pautas para la lactancia y el consumo de sustancias o trastorno por consumo de sustancias, revisado en 2015. Breastfeed Med. 2015 Full text (link to original source) Full text (in our servers)
  4. Kocherlakota P. Neonatal abstinence syndrome. Pediatrics. 2014 Abstract Full text (link to original source) Full text (in our servers)
  5. Sutter MB, Leeman L, Hsi A. Neonatal opioid withdrawal syndrome. Obstet Gynecol Clin North Am. 2014 Abstract
  6. Bagley SM, Wachman EM, Holland E, Brogly SB. Review of the assessment and management of neonatal abstinence syndrome. Addict Sci Clin Pract. 2014 Abstract Full text (link to original source) Full text (in our servers)
  7. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  8. D'Apolito K. Breastfeeding and substance abuse. Clin Obstet Gynecol. 2013 Abstract
  9. Logan BA, Brown MS, Hayes MJ. Neonatal abstinence syndrome: treatment and pediatric outcomes. Clin Obstet Gynecol. 2013 Abstract Full text (link to original source) Full text (in our servers)
  10. Welle-Strand GK, Skurtveit S, Jansson LM, Bakstad B, Bjarkø L, Ravndal E. Breastfeeding reduces the need for withdrawal treatment in opioid-exposed infants. Acta Paediatr. 2013 Abstract
  11. Pritham UA, Paul JA, Hayes MJ. Opioid dependency in pregnancy and length of stay for neonatal abstinence syndrome. J Obstet Gynecol Neonatal Nurs. 2012 Abstract Full text (link to original source) Full text (in our servers)
  12. Yep T, Eyal S, Easterling TR, Shen DD, Kelly EJ, Hankins GDV, Caritis S, Risler L, Hebert MF. The pharmacokinetics of metoprolol during pregnancy. American College of Clinical Pharmacy 2011 Annual Meeting. Abstract 471. Pharmacotherapy. 2011;31:439e. 2011 Full text (link to original source) Full text (in our servers)
  13. WHO Expert Committee on Drug Dependence. Critical review of psychoactive substances. WHO Technical Report Series. Thirty-third Report 2003 Full text (link to original source) Full text (in our servers)
  14. OMS. Comité de Expertos de la OMS en Farmacodependencia. Examen crítico de psicofármacos. OMS. Serie de informes técnicos, 33 informe. 2003 Full text (in our servers)
  15. Hirose M, Hosokawa T, Tanaka Y. Extradural buprenorphine suppresses breast feeding after caesarean section. Br J Anaesth. 1997 Abstract Full text (link to original source) Full text (in our servers)

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