Last update: March 22, 2018

9α-Fluoro-16β-methylprednisolone

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Because pharmacokinetic data suggest excretion into breast milk in significant levels long lasting treatments should use other steroidal drugs known to be excreted in low amounts.

When administered before delivery it may induce delay in phase II of Lactogenesis (coming-in) and a decrease of milk production within the first week post-partum.

Large intra-articular doses may transitory decrease milk production.

WHO Model List of Essential Drugs 2002: Compatible with breastfeeding.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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Other names

9α-Fluoro-16β-methylprednisolone is also known as Betamethasone. Here it is a list of alternative known names::


9α-Fluoro-16β-methylprednisolone in other languages or writings:

Group

9α-Fluoro-16β-methylprednisolone belongs to this group or family:

Tradenames

Main tradenames from several countries containing 9α-Fluoro-16β-methylprednisolone in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 393 daltons
Protein Binding 64 %
Tmax 0,2 - 0,5 hours
T1/2 5,6 hours

References

  1. Babwah TJ, Nunes P, Maharaj RG. An unexpected temporary suppression of lactation after a local corticosteroid injection for tenosynovitis. Eur J Gen Pract. 2013 Abstract
  2. Dennis CL, Schottle N, Hodnett E, McQueen K. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: a randomized controlled trial. Breastfeed Med. 2012 Dec;7(6):473-9. Abstract
  3. McGuire E. Sudden loss of milk supply following high-dose triamcinolone (Kenacort) injection. Breastfeed Rev. 2012 Abstract
  4. Henderson JJ, Newnham JP, Simmer K, Hartmann PE. Effects of antenatal corticosteroids on urinary markers of the initiation of lactation in pregnant women. Breastfeed Med. 2009 Abstract
  5. Henderson JJ, Hartmann PE, Newnham JP, Simmer K. Effect of preterm birth and antenatal corticosteroid treatment on lactogenesis II in women. Pediatrics. 2008 Abstract Full text (link to original source) Full text (in our servers)
  6. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  7. Lockshin MD, Sammaritano LR. Corticosteroids during pregnancy. Scand J Rheumatol Suppl. 1998 Abstract
  8. Amir L. Eczema of the nipple and breast: a case report. J Hum Lact. 1993 Abstract
  9. Martell M, Oehninger C, Scotti C, Delgado L, Martĭnez M, Korc I. Influence of glucocorticoid and betamimetic therapy on milk secretory IgA concentration produced by mothers delivering preterm infants. J Perinat Med. 1985 Abstract

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