Last update: Jan. 14, 2019

1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulphonate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

It is an alpha-1-adrenergic blocking agent that is used for treatment of arterial hypertension and of obstructive symptoms resulting from benign prostatic hypertrophy.
Oral administration once a day.

Its pharmacokinetic data (moderately elevated molecular weight, high percentage of plasma protein binding and high volume of distribution) (Pfizer 2017, Kirsten 1998, Elliot 1987) probably explain the negligible excretion observed in milk (Pfizer 2017, Versmissen 2016, Jensen 2013 y 2014).

Until more extensive published data about this drug regarding breastfeeding are available a safer alternative drug may be used (Anderson 2018, Schaefer 2007 p685), especially during the neonatal period and/or in case of premature infants.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulphonate is Doxazosin Mesylate in Chemical name.

Is written in other languages:

Group

1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulphonate belongs to this group or family:

Tradenames

Main tradenames from several countries containing 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulphonate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 65 - 68 %
Molecular weight 548 daltons
Protein Binding 98 - 99 %
VD 1,3 l/Kg
pKa 7,2 -
Tmax 2 (retard: 8 - 9) hours
T1/2 19 - 22 hours
M/P ratio 0,1 -
Theoretical Dose 0,0004 - 0,0006 mg/Kg/d
Relative Dose 0,6 - 0,9 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Pfizer. Doxazosina. Ficha técnica. 2017 Full text (in our servers)
  3. PhI (Pharmascience Inc). Doxazosin. Drug Summary. 2017 Full text (in our servers)
  4. Versmissen J, Koch BC, Roofthooft DW, Ten Bosch-Dijksman W, van den Meiracker AH, Hanff LM, Visser W. Doxazosin treatment of phaeochromocytoma during pregnancy: placental transfer and disposition in breast milk. Br J Clin Pharmacol. 2016 Abstract
  5. (Jensen BP, Dalrymple JM, Begg EJ) Corrigendum: Transfer of doxazosin into breast milk. J Hum Lact. 2013 J Hum Lact. 2014 Abstract
  6. Jensen BP, Dalrymple JM, Begg EJ. Transfer of doxazosin into breast milk. J Hum Lact. 2013 Abstract
  7. Schaefer C, Peters P, Miller RK. Drugs During Pregnancy and Lactation. Treatment options and risk assessment. Elsevier, second edition. London. 2007
  8. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract
  9. Elliott HL, Meredith PA, Reid JL. Pharmacokinetic overview of doxazosin. Am J Cardiol. 1987 Abstract

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